Contacts between Influenza Virus N9 Neuraminidase and Monoclonal Antibody NC10
نویسندگان
چکیده
منابع مشابه
Antibody response in man to influenza virus neuraminidase following influenza.
Genetic recombination of influenza viruses of different subtype may result in segregation of hemagglutinin and neuraminidase in antigenically hybrid viruses [E. D. Kilbourne et al., in M. Pollard (ed.), Perspectives in Virology, vol. 5, p. 87, Academic Press, Inc., N.Y., 1967; and W. G. Laver and E. D. Kilbourne, Virology 30:493, 1966]. The selective use of such antigenic hybrids in serological...
متن کاملEffect of influenza anti-neuraminidase antibody on virus neutralization.
Antibody to influenza virus neuraminidase participates in tissue culture neutralization tests in which inhibition of hemadsorption is the end point. Presumably, by inhibiting virus release it functions additively with anti-hemagglutinin in reducing total virus replication.
متن کاملInfluenza virus neuraminidase.
Antiserum specific for influenza A2 neuraminidase was produced by immunization of rabbits with the purified enzyme which had been isolated by electrophoresis from the proteins of a detergent-disrupted AoA2 influenza virus recombinant [X-7 (Fl)]. This recombinant contained hemagglutinin of the Ao subtype and A2 neuraminidase. Antiserum to the isolated A2 neuraminidase did not react in any of fou...
متن کاملInfluenza Virus Neuraminidase: Structure and Function
The structure of the influenza virus neuraminidases, the spatial organization of their active site, the mechanism of carbohydrate chains desialylation by neuraminidase, and its role in the influenza virus function at different stages of the viral infectious cycle are considered in this review. Data on the neuraminidase substrate specificity and different approaches in studying the activity of t...
متن کاملUse of reverse transcriptase PCR to subtype N1 to N9 neuraminidase genes of avian influenza viruses.
Reverse transcriptase PCR designed to amplify the N1 to N9 neuraminidase (NA) genes of avian influenza viruses detected 118 of the 119 NA genes tested (99.2%) in a subtype-specific manner. This technique successfully subtyped all 167 recent avian influenza viruses isolated from birds. Subtype specificity was confirmed by sequence analyses of all 285 PCR products.
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ژورنال
عنوان ژورنال: Virology
سال: 2002
ISSN: 0042-6822
DOI: 10.1006/viro.2002.1564